In the benign group, the mean duration of the enlarged LAP was 8.30☗.18 weeks in the malignant group, the mean duration of the LAP was 7.05±5.38 weeks. The duration of LAPs was examined in two groups according to the histopathological characteristics: Benign and malignant. The LAP size was categorized as either 0.05). Malignant lesions were significantly correlated to patients aged >40 years (p=0.009). Malignancy rates were 13.6% in patients aged 40 years. The patients were categorized according to three age groups: 40 years. No significant correlations were found between lymph node location and malignancy (p>0.05). Lymph node excision was performed on the right side on 71 (43.8%) patients and on the left side in 91 (56.2%) patients. Malignant lesions were significantly higher in males than in females (p=0.002). When analyzing the relationship between gender and malignancy, malignancy rates were observed in 23.9% of female patients and 51.7% of male patients. The histopathological distribution of the lymph nodes. The parameters that could be used to predict LAP malignancy were determined from these data.Įthics committee approval was obtained from the Pamukkale University clinical research ethics committee (60116787-020/54307). The duration of the enlarged lymph node was determined according to the first symptom date reported by the patients. Lymph node localizations were evaluated according to sides and neck levels. Likewise, lymph node size was classified as either <3 cm or ≥3 cm. Patient ages were stratified into three groups: 40 years. Demographic data and the size, duration, and localization of LAP were recorded, and their relationship with histopathological results was investigated. A total of 162 patients met the inclusion criteria and were included in the study. Patients were excluded from the study if a primary disease had already been established or if detailed history and surgery notes were inaccessible. Lymph nodes with a diameter exceeding 1 cm, that are unresponsive to antibiotic treatment, and that have not regressed for a period exceeding 3 weeks, were considered “persistent LAP” in our study. We retrospectively analyzed the files of patients diagnosed with persistent cervical LAP who had undergone an excisional biopsy in the ear, nose, and throat (ENT) department of Pamukkale University Hospital between January 2011 and October 2019. The present study aims to compare clinical and histopathological data of patients who had undergone excisional biopsy in our department to determine the parameters that can be used to predict malignancy in persistent cervical LAPs. To prevent unnecessary surgery on the patient and to detect malignancy as early as possible, understanding and recognizing the symptoms of LAP malignancy are crucial. However, the most important problem facing the diagnosis of LAP is determining the most appropriate candidate and time point for excisional biopsy. In the diagnosis of persistent LAP, excisional biopsy is the gold standard diagnostic method, and it can be safely performed with minimal morbidity and mortality. Furthermore, excisional biopsy is required for the diagnosis of lymphoma. Although fine-needle aspiration biopsy is useful in benign-malignant differentiation, it often fails to establish a definitive diagnosis. However, a biopsy is required for diagnosis, especially in cases that do not regress with antibiotic therapy or if a systemic disease is suspected. In both adults and children, enlarged cervical lymph nodes are mostly benign and tend to regress spontaneously or by treatment. LAP can be caused by infectious diseases (e.g., viral, bacterial, fungal, and parasitic), some non-infectious diseases (e.g., sarcoidosis, connective tissue disorders, etc.), lymphoproliferative diseases, and other infiltrative malignant diseases. LAP results from the proliferation of neoplastic or inflammatory cells in the lymph node. Lymphadenopathy (LAP) is defined as an abnormality in the size and characteristics of a given lymph node.
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